The study results showed that the antibody responses were significantly increased in both probiotic groups compared to placebo after a challenge of the immune system. The study abstract – Probiotic strains BB-12 and L. casei 431 increase the immune response to an influenza vaccine: A randomized, double-blind, placebo-controlled study – was presented on 28 October 2010 at the 2nd World Congress on Immunity Ingredients, Malta.
The study investigated the impact of Chr Hansen’s probiotic strains BB-12 and L. casei 431 on the functional capacity of the immune system by measuring specific antibody responses to an influenza vaccination.
Antibody responses in such a vaccination model have been identified by experts as being the best marker currently available to evaluate the human immune response.
The study, managed by Sprim Italy, was conducted at the Luigi Sacco Hospital in Milan and included 211 healthy adults.
“These results offer strong evidence that the functionality of the immune system can be improved by dietary supplementation with these probiotic strains,” said Professor Mario Clerici, director, Department of Biomedical Science and Technology, University of Milan. “No drugs are available to improve the effects of vaccinations or to augment the level of immune mediated protection against infections. This can apparently be achieved with dietary supplementations.”
“This study – which is part of our comprehensive clinical study programme – documents that supplementation with our probiotics induces multiple and complementary parts of the immune system. This is promising,” said Chr Hansen’s Birgit Michelsen, director of scientific affairs, Health & Nutrition Division. “The outcomes of this study, as well as data from previous studies on BB-12 and L. casei 431, show that supplementation with these probiotic strains result in a strengthening of various parts of the immune system. This will very likely translate into a clinical benefit, such as reduced rates of infection. However, studies designed specifically to assess infections are needed to determine this.”
Source: Chr Hansen
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